We participated to the Special Issue "Ion Channels in Sperm Physiology 2.0" of the International Journal of Molecular Sciences by reviewing the mutations in ion transporters and channels genes leading to human asthenozoospermia. Additional clues from pharmacological and proteomics studies, as well as from KO animal models, were listed too. This genetic overview is also enriched by perspectives about potential applications in infertility therapy and male contraception.
To read the full review: https://www.mdpi.com/1422-0067/23/7/3926
International Journal of Molecular Sciences 23, (2022)